Aripiprazole action

Aripiprazole is an atypical antipsychotic orally indicated for treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's Label. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania Label Aripiprazole is a quinoline derivate and atypical anti-psychotic agent. Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors. This drug stabilizes dopamine and serotonin activity in the limbic and cortical system. Aripiprazole is used in managing symptoms of schizophrenia and.

Aripiprazole Prevents Rats From Resuming Cocaine Seeking

Aripiprazole: Uses, Interactions, Mechanism of Action

Aripiprazole C23H27Cl2N3O2 - PubChe

molecule, aripiprazole, and these features are discussed here. Take-Home Points ' Brexpiprazole, like aripiprazole, is a dopamine multifunctionalagent.Bothhavedopamineandserotonin receptor partial agonism as their pharmacological mechanism of action. Both are also known as atypical antipsychotics and as adjunctive antidepressants Aripiprazole, sold under the brand name Abilify among others, is an atypical antipsychotic. It is primarily used in the treatment of schizophrenia and bipolar disorder. Other uses include as an add-on treatment in major depressive disorder, tic disorders and irritability associated with autism. It is taken by mouth or injection into a muscle aripiprazole increases effects of atropine IV/IM by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia. atropine IV/IM decreases levels of..

The mechanism of action of aripiprazole, as with other drugs having efficacy in schizophrenia and bipolar disorder, is unknown. However, it has been proposed that the efficacy of aripiprazole is mediated through a combination of partial agonist activity at D2 and 5-HT1A receptors and antagonist activity at 5-HT2A receptors. Actions a Abilify (aripiprazole) is an anti-psychotic medicine used for the medical treatment of psychotic conditions and disorders such as schizophrenia and bipolar disorder. It also is used with other medications for the treatment of major depression in adults. The exact mechanism of action of Abilify is unknown Mechanism of action. It has been proposed that aripiprazole's efficacy in schizophrenia and Bipolar I Disorder is mediated through a combination of partial agonism at dopamine D 2 and serotonin 5-HT 1A receptors and antagonism of serotonin 5-HT 2A receptors. Aripiprazole exhibited antagonist properties in animal models of dopaminergic.

Aripiprazole 5mg tablets. This information is intended for use by health professionals. 1. Name of the medicinal product. Aripiprazole Milpharm 5 mg tablets. 2. Qualitative and quantitative composition. Each tablet contains 5 mg of aripiprazole. Excipient with known effect: 76 mg lactose monohydrate per tablet Aripiprazole acts as partial dopamine agonist thereby produces less extrapyramidal side effects. It can also be used in other disorders like autism and bipol..

Brexpiprazole, like aripiprazole, is a dopamine multifunctional agent. Both have dopamine and serotonin receptor partial agonism as their pharmacological mechanism of action. Both are also known as atypical antipsychotics and as adjunctive antidepressants To summarize, aripiprazole, as a dopamine partial agonist, acts as a modulator of dopamine effects. When present, it diminishes the effects of both dopamine excess (by decreasing dopamine action when there is too much of it) and deficit (by increasing dopamine action when there is too little of it). Was this page helpful

TEVA-ARIPiprazole Warning There is a higher chance of death in older adults who take this drug for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This drug is not approved to treat mental problems caused by dementia. Drugs like this one have raised the chance of suicidal thoughts or actions i Aripiprazole is the first antipsychotic agent with D2 partial agonist properties. 11 Similar to other antipsychotics, the exact mechanism of action of aripiprazole for the treatment of schizophrenia is unknown but is believed to involve D2 and 5HT1A receptor partial agonism and 5HT2A receptor antagonism. 10 Aripiprazole is hypothesized to act as a partial agonist at both D2 autoreceptors and postsynaptic receptors. 12 Effects at D2 autoreceptors may result in reduced dopamine synthesis and. Aripiprazole is a dopamine D 2 partial agonist with weak 5-HT 1a partial agonism and 5-HT 2A receptor antagonism. Indications and dose Maintenance of schizophrenia in patients stabilised with oral aripiprazole (CYP2D6 poor metabolisers Mechanism of Action. Aripiprazole is a quinolinone antipsychotic that is a partial agonist at the D2 and 5HT-1a receptors and an antagonist at 5HT-2a receptor. It has a high affinity for D2, D3, 5HT-1a, and 5HT2a receptors and moderate affinity for D4, 5HT-2c, 5-HT7, alpha-1 adrenergic, and H1 receptors

Posted in Class Action Lawsuits. Aaripiprazole, better known by the brand name Abilify, was first discovered in 1995 by Japanese scientists working for Otsuka Pharmaceutical. In 2002, the FDA approved Abilify as a medication to treat schizophrenia in adults. The development of the drug had taken seven years under the investment of Bristol-Myers. Aripiprazole, which is a major pharmacological metabolite of aripiprazole lauroxil, serves to improve the positive and negative symptoms of schizophrenia by modulating dopaminergic signalling pathways. Aripiprazole lauroxil is reported to have minimal effects on sexual function or prolactin levels 7. Mechanism of action

Aripiprazole - Side Effects and more Pharmacyboo

ARIPiprazole: Dosage, Mechanism/Onset of Action, Half-Life

  1. e D 2 and serotonin 5-HT 1A receptors, and as an antagonist at serotonin 5-HT 2A receptors. Onset: Aripiprazole: 1-3 weeks (initial); Aripiprazole lauroxil: Within 4 days (concomitant use with oral aripiprazole therapy). Pharmacokinetics
  2. The patient was commenced on aripiprazole, a relatively novel antipsychotic drug, not associated with an increase in prolactin levels. Over a 10-year follow up, the authors report that use of this drug led to improved psychotic symptoms, normalised prolactin levels and a decrease in prolactinoma size. They conclude that aripiprazole can be a.
  3. ergique D2 et sérotoninergique 5-HT1a et de son activité antagoniste sur le récepteur sérotoninergique 5-HT2a
Aripiprazole 10mg Tablets - Rosheta Oman

Find Aripiprazole Mechanism Action stock images in HD and millions of other royalty-free stock photos, illustrations and vectors in the Shutterstock collection. Thousands of new, high-quality pictures added every day 1: aripiprazole lauroxil [Supplementary Concept] Date introduced: December 31, 2015 Registry Number: B786J7A343 Heading Mapped to: Aripiprazole Entry Terms: Aristada Pharmacologic Action: Antipsychotic Agents All MeSH Categories aripiprazole lauroxil 2: Aripiprazole An antipsychotic agent that is structurally related to piperazines and quinolones Aripiprazole is a 'second-generation antipsychotic' (sometimes described as an 'atypical antipsychotic'). Research suggests that mania and psychosis are more likely to occur when parts of the brain have too much of a chemical called dopamine. This theory is based on the fact that amfetamines, which are stimulants that release dopamine, can bring on psychosis in people who do not have. a low seizure threshold. a low supply of oxygen rich blood to the heart. chronic heart failure. a disorder of the blood vessels of the brain. orthostatic hypotension, a form of low blood pressure. Read More. The onset of action ranges from 45 minutes - 1 ½ hours, and the duration of action is six hours. Diazepam carries a bi-phasic half-life of 20-50 hours (for Diazepam), and 30-200 hours (for Desmethyldiazepam). Valium is indicated for the long-term management of generalized anxiety and tension-anxiety

Aripiprazole, A Drug that Displays Partial Agonism and

  1. e receptor-binding profile distinct from other second-generation antipsychotics. Aripiprazole acts as partial agonist at dopa
  2. e antagonist action of aripiprazole may di
  3. e signaling, introducing for the first time in the treatment of psychosis a clinically relevant mechanism based on D2R occupancy without D2R blockade. Beyond its peculiar action on D2Rs, preclinical and in vivo studies in humans hav
  4. e D2 receptor partial agonist with partial agonist activity at serotonin 5HT1A receptors and antagonist activity at 5HT2A receptors. This multicenter trial exa

Aripiprazole is a dihydroquinolinone, structurally unrelated to the other antipsychotics. It was approved for the treatment of schizophrenia in 2002 and subsequently for bipolar or mixed mania. It exhibits a novel mechanism of action as a partial agonist at the D 2 receptor with approximatel Action View Abilify mechanism of action for pharmacodynamics and pharmacokinetics details View Aripiprazole.docx from NURSING 140 at Des Moines Area Community College. Aripiprazole Antipsychotic Mechanism of Action: Provides partial agonist activity related to dopamine and serotoni Aripiprazole , a novel antipsychotic, is a high-affinity. The peculiarity of the mechanism of action of aripiprazole at D2Rs is also suggested by the fact that aripiprazole, differently from a canonical D2R agonist and/or partial agonist, does not elicit a contraversive rotation in rats with a unilateral lesion of nigrostriatal pathway induced by 6-OH-dopamine Mechanism of Action. Aripiprazole lauroxil is a prodrug of aripiprazole. Following intramuscular injection, aripiprazole lauroxil is likely converted by enzyme-mediated hydrolysis to N-hydroxymethyl aripiprazole, which is then hydrolyzed to aripiprazole

View Rhea Aripiprazole overdosage for action to be taken in the event of an overdose. Administration . May be taken with or without food. Contraindications . Hypersensitivity. Pruritus/urticaria, anaphylaxis. Click to view Rhea Aripiprazole detailed prescribing information. mechanism of action. Partial agonism at D2 receptors, partial agonism to 5HT 1A and 2A receptors,. Targets postitive, negative , cognitive and affective symptoms of scz or bipolar disorder Aripiprazole may be preferable to anticonvulsant mood stabilizers if treatment is requiered during pregnancy. reasons to be well accepted

Aripiprazole is a 3rd generation atypical antipsychotic U.S. Food and Drug Administrationapproved for the treatment of schizophrenia, bipolar disorder, and treatment-resistant major depression. Its principal mechanism of action appears to be associated with partial agonism at the D2 dopamine receptor Abilify Aripiprazole Manufacturer: Otsuka/Bristol Myers-Squibb Labeled Indications: Abilify is an antipsychotic drug indicated for the treatment of certain mental disorders, such as schizophrenia, bipolar disorder, Tourette's disorder, and irritability associated with autistic disorder. It may also be used in combination with antidepressants to treat depression Brexpiprazole [7-{4-[4-(1-benzothiophen-4-yl) piperazin-1-yl]butoxy}quinolin-2(1H)-one] is a novel atypical antipsychotic that is structurally similar to the atypical antipsychotic, aripiprazole. It has the following key psychopharmacological properties Abilify: L'aripiprazole appartient au groupe de médicaments appelés antipsychotiques. Il s'utilise pour soigner la schizophrénie et le trouble bipolaire. L'aripiprazole ne constitue pas un traitement curatif de ces troubles médicaux, mais il aide à prendre en charge leurs symptômes en modifiant les actions de certains messagers chimiques dans le cerveau Initiation and Dosing ABILIFY MAINTENA is a once-monthly LAI you can initiate from any oral antipsychotic Recommended starting and maintenance dose of ABILIFY MAINTENA is 400 mg once monthly 1. For patients without a history of aripiprazole use, establish tolerability for up to 2 weeks with oral aripiprazole prior to initiating therap

ARIPiprazole (Professional Patient Advice) - Drugs

Aripiprazole is a medication that works in the brain to treat schizophrenia. It is also known as a second generation antipsychotic (SGA) or atypical antipsychotic. Aripiprazole rebalances dopamine and serotonin to improve thinking, mood, and behavior. Symptoms of schizophrenia include Abilify (aripiprazole) is an antipsychotic drug used for the management of schizophrenia, depression, autistic disorder, and mood disorders. It acts by normalizing the production of important neurotransmitters in the brain such as serotonin and dopamine. It was approved for use in the U.S. market by the Food and Drug Administration (FDA) in 2002 Biochem/physiol Actions. Aripiprazole is a second generation atypical antipsychotic and anti-depressant with partial agonist activity at dopamine D2 and serotonin 5-HT1A receptors and antagonist activity at serotonin 5-HT2A receptors. Ki values are 0.34 nM, 0.8 nM, 1.7 nM, and 3.4 nM, respectively, for dopamine D2 and D3, serotonin 5-HT1A and 5.

Aripiprazole: Side Effects, Dosage, Uses, and Mor

aripiprazole-treated patients reported cerebrovascular adverse reactions compared with 0.6 % of placebo-treated patients in these trials. This difference was not statistically significant. However, in one of these trials, a fixed- dose trial, there was a significant dose response relationship fo The mechanism of action is unknown. Efficacy of aripiprazole may be mediated through a combination of partial agonist activity at D 2 and 5-HT 1A receptors and antagonist activity at 5-HT 2A receptors. Actions at other receptors may explain some other clinical effects of aripiprazole (e.g., orthostatic hypotension)

أريبيبرازول - ويكيبيدي

  1. e is excessively fired there this aripiprazole acts as an antagonist thereby prevents excessive.
  2. aripiprazole induces almost no sedative action in patients. In conclusion, the present results suggest that the favourable efficacy and side-ef fect profile of aripiprazole seen in multipl
  3. Adding aripiprazole to SSRIs or SNRIs did not significantly improve depression in this study. the authors are comparing aripiprazole with no action, a situation that wouldn't happen in the.
Effective Drugs And Medications For Autism - Medicines for

Background: Antipsychotics modulate expression of inflammatory cytokines and inducible inflammatory enzymes. Elopiprazole (a phenylpiperazine antipsychotic drug in phase 1) has been characterized as a therapeutic drug to treat SARS-CoV-2 infection in a repurposing study. We aim to investigate the potential effects of aripiprazole (an FDA approved phenylpiperazine) on COVID-19-related. Aripiprazole is less effective in treating schizophrenia than olanzapine (Zyprexa), but has fewer metabolic and sedative adverse effects. There is no difference in effectiveness between. Abilify is an anti-psychotic medication that alters how different chemicals work in the brain that control our moods along with other psychological aspects. It's used to treat: manic-depression.

We analysed 239 cases, 86 concerning single-drug exposures to aripiprazole, and 153 cases where aripiprazole had been taken with at least one other substance (mixed-drug). The median ingested aripiprazole dose was 105 mg (IQR: 50-1680 mg) in the single-drug exposure group and 120 mg (IQR: 60-225 mg) in the mixed-drug exposure group Mécanisme d'action. L'efficacité de l'aripiprazole dans la schizophrénie et dans les troubles bipolaires de type I pourrait être due à l'association de son activité agoniste partielle sur le récepteur dopaminergique D 2 et sérotoninergique 5-HT 1A et de son activité antagoniste sur le récepteur sérotoninergique 5-HT 2A



Mechanism of Action: Unclear, thought to be mediated through a combination of partial agonist activity at D 2 and 5-HT 1A receptors and antagonist activity at 5-HT 2A receptors. Aripiprazole drug-device combination system: consists of four components . 1. Aripiprazole tablet embedded with an IEM sensor 2. Mycite ABILIFY is not approved for use in pediatric patients with depression (see BOXED WARNING). Do not take ABILIFY if you are allergic to aripiprazole or any of the ingredients in ABILIFY. Allergic reactions have ranged from rash, hives, and itching to anaphylaxis, which may include difficulty breathing, tightness in the chest, and swelling of the. Aripiprazole, an Antipsychotic With a Novel Mechanism of Action, and Risperidone vs Placebo in Patients With Schizophrenia and Schizoaffective Disorder Archives of General Psychiatry, 2003 Mirza Al

Are All Atypical Antipsychotics Equal for the Treatment of

Aripiprazole, an antipsychotic with a novel mechanism of

  1. e system stabilisers.! Whether the novel mode of action of aripiprazole will translate into significan
  2. The action of aripiprazole and brexpiprazole at the receptor level in singultus: Eman Alefishat 1, 2, 3, Lujain Aloum 1, Ovidiu C Baltatu 1, Georg A Petroianu 1, * (): 1 Department of Pharmacology, College of Medicine and Health Science, Khalifa University of Science and Technology, 127788 Abu Dhabi, United Arab Emirates 2 Center for Biotechnology, Khalifa University of Science and Technology.
  3. Aripiprazole for schizophrenia, bipolar disorder and tics. This leaflet is about the use of aripiprazole for the treatment of schizophrenia and bipolar disorder (sometimes called psychotic disorders) and tics, such as seen in Tourette's syndrome

Abilify: Uses, Dosage & Side Effects - Drugs

  1. This is a quick reference drug monograph for the antipsychotic, aripiprazole (Abilify)
  2. Aripiprazole belongs to a group of medicines called antipsychotics. It is taken once daily. Keep your regular appointments with your doctor. This is so your progress can be checked. The most common side-effects include feeling shaky and restless. Aripiprazole. Abilify. In this article. About aripiprazole
  3. Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder Arch. Gen. Psychiatry , 60 ( 2003 ) , pp. 681 - 69
  4. abilify onset of action. Aripiprazole: a novel atypical antipsychotic drug with a uniquely. aripiprazole (Abilify) - drug class, medical uses, medication side. Aripiprazole (Abilify) is an atypical antipsychotic drug that has been recently. In short-term studies rapid onset of action (within one week) has been demonstrated
  5. ergiques et 5-hydroxytrypta
  6. Aripiprazole - Abilify® 10 mg, 15 mg, 20 mg : action et effets thérapeutiques, prix, taux de remboursement Sécu, condition de prescription, contre-indications, posologie, grossesse. Acheter Abilify sans ordonnanc
  7. Aripiprazole is similar in effectiveness to risperidone and somewhat better than ziprasidone. Aripiprazole had less side- effects than olanzapine and risperidone (such as weight gain, sleepiness, heart problems, shaking and increased cholesterol levels). Aripiprazole was not as good as ziprasidone for dealing with restlessness or people's.

Aripiprazole: MedlinePlus Drug Informatio

Request PDF | Mechanism of action of brexpiprazole: Comparison with aripiprazole | Brexpiprazole is a new therapeutic agent that was recently approved for the treatment of schizophrenia and for. The claimed indication for Abilify Maintena is maintenance treatment of schizophrenia in adults. Schizophrenia is a chronic, disabling, and progressive disease characterized by delusions, hallucinations, and cognitive impairment; symptoms and disease course differ across patients Abilify Class Action Lawsuit Allegations. The plaintiffs allege in the Abilify class action lawsuit that aripiprazole can cause compulsive conduct and an inability to control impulsive behaviour. The specific behaviours that are allegedly linked to Abilify and Abilify Maintena include pathological gambling, compulsive shopping and spending.

Aripiprazole Long-Acting Injection (Abilify Maintena®) Guidelines for Prescribing and Administration (Version 3 - August 2014) 1. Key Points. 1.1 Aripiprazole long acting injection (LAI) is licensed / indicated for the maintenance treatment of adult patients with schizophrenia, whose condition has been stabilised with oral aripiprazole Abilify tablets, orodispersible tablets, oral solution and injection all contain the active ingredient aripiprazole, which is a type of medicine known as an atypical antipsychotic. The way in. Abilify Un essai récemment mené sur le marché a permis à Abilify® d'indiquer le traitement d'entretien du trouble bipolaire. Cet essai a été mené dans environ 30 centres d'essais cliniques américains et dans deux autres centres d'essais cliniques au Mexique. Dans les centres d'essais basés aux États-Unis Aux États-Unis, lorsque vous avez ajouté tous le Aripiprazole is an atypical antipsychotic agent with a novel mechanism of action that has been successfully employed in medication therapy for schizophrenia and schizoaffective disorders (1, When aripiprazole lauroxil is dissolved in the body, Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the D2. Aripiprazole will be started at 5 mg and uptitrated in a treat-to-target fashion by 5 mg at monthly intervals until prolactin has normalized or decreased sufficiently to restore menses in the women and a normal testosterone in the men. Maximum aripiprazole dose will be 30 mg. Secondary Outcome Measures

Mechanism of action of brexpiprazole: comparison with

Aripiprazole lauroxil is a long-acting injectable atypical antipsychotic drug used in the treatment of schizophrenia in adult patients. It is a prodrug of [aripiprazole], which acts as a partial agonist at the D2 and 5-HT1A receptors, and as an antagonist at the 5-HT2A receptors.Affecting about 1% of the adult population in the United States and approximately 26 million people worldwide. Abilify lawsuits claim manufacturers did not warn patients of serious side effects. Some say the antipsychotic drug caused compulsive gambling and eating. Users also reported issues with compulsive shopping and sex. More than 2,800 Abilify lawsuits have been filed. Some cases have settled for a total of $534 million

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Aripiprazole - Wikipedi

Class-actions for Abilify patients. There are currently no class actions against Abilify. There are differences between a class action and MDLs. Before any class action starts, the plaintiffs require certification as a single class. The Federal Rules of Civil Procedure states a class can be certified if: 1. There are questions of law or fact. Abilify Epithelium Hummingbird is a clear, asinine to light-yellow solution different in a concentration of 1 mgmL. The downward mechanisms of action for abilify for this solution even disodium edetate, milligram, glycerin, dl-lactic dripping, methylparaben, ambassador drag, propylparaben, sodium hydroxide, diagnosis, and threw gravy ABILIFY ® (a BIL ĭ fī 1. Antidepressant medicines may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment. 2. Abilify (aripiprazole) is an orally administered drug approved in November 2002 for the treatment of schizophrenia. It is a dopamine partial agonist and a seratonin antagonist. Abilify oral tablets are available in 10mg, 15mg, 20mg, and 30mg doses. The 15mg strength is the recommended starting and effective dose J0400. Injection, aripiprazole, intramuscular, 0.25 mg. Drugs administered other than oral method, chemotherapy drugs. J0400 is a valid 2021 HCPCS code for Injection, aripiprazole, intramuscular, 0.25 mg or just Aripiprazole injection for short, used in Medical care

Abilify Maintena, Aristada (aripiprazole) dosing

The mechanism of action of aripiprazole in schizophrenia or bipolar mania, is unclear. However, the efficacy of aripiprazole in the listed indications could be mediated through a combination of partial agonist activity at D 2 and 5-HT 1A receptors and antagonist activity at 5-HT 2A receptors Aripiprazole. This risk may persist until significant remission occurs. These side effects may lead to falls which could cause bone fractures or other injuries. Results from method validation can be used to judge the quality, reliability aripiprazole mechanism of action consistency of analytical results Aripiprazole, an antipsychotic with a novel mechanism of action, and risperidone vs placebo in patients with schizophrenia and schizoaffective disorder. Arch Gen Psychiatry. 2003 Jul;60(7):681-90 Abilify Maintena is an extended release intramuscular injection. The key benefit is it only needs to be injected once monthly. This product is quite expensive, but cuts down on patients forgetting to take the medication. Abilify Mycite is a high tech form of aripiprazole tablets. The tablets actually have an embedded sensor that allows them to.

Save on ABILIFY MAINTENA *. You may be eligible to start saving on your ABILIFY MAINTENA prescription by taking this card to your next injection appointment.*. Eligible patients may pay as little as $10 per 30-day calendar month with an annual maximum benefit of $8,000 and monthly $1,400 maximum A Quebec court has authorized a proposed Class in an Abilify class action lawsuit alleging those who took the antipsychotic medication suffered from compulsions to shop, gamble, overeat, and even have sex. Lead plaintiff S. Scheer lodged the complaint against Bristol-Myers Squibb Canada, Otsuka Canada Pharmaceutical, and Lundbeck Canada seeking. Laparoscopic salp- of abilify aripiprazole mechanism action ingotomy is appropriate if the patient attribute their symptoms, the presence of visible contralateral tubal disease. If action is required to provoke changed behaviour from others. But unwanted pregnancies can be distinguished from the hypothalamus, if corticosteroid therapy is started The action of aripiprazole and brexpiprazole at the receptor level in singultus. J Integr Neurosci. 2021 Mar 30; 20(1):247-254. JI. Abstract. The hiccup (Latin singultus) is an involuntary periodic contraction of the diaphragm followed by glottic closure, which can be a rare side effect of aripiprazole. In contrast to the structurally closely. INDICATIONS. ABILIFY MAINTENA ® (aripiprazole) is a prescription medicine given by injection by a healthcare professional for:. treatment of schizophrenia in adults; maintenance treatment of bipolar I disorder in adults; It is not known if ABILIFY MAINTENA is safe and effective in children under 18 years of age